Wilfred A van der Donk Selected Research

lacticin 481

1/2016	Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis.
7/2008	The importance of the leader sequence for directing lanthionine formation in lacticin 481.
5/2007	Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity.
5/2007	Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis.
2/2007	On the substrate specificity of dehydration by lacticin 481 synthetase.
2/2006	The dehydratase activity of lacticin 481 synthetase is highly processive.

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Wilfred A van der Donk Research Topics

Disease

35	Dehydration (Water Stress) 01/2021 - 07/2002
2	Cystitis 01/2021 - 08/2012
2	Infections 03/2019 - 01/2017
2	Neoplasms (Cancer) 10/2018 - 11/2008
2	Cystic Fibrosis (Mucoviscidosis) 10/2018 - 01/2017
1	Communicable Diseases (Infectious Diseases) 01/2021
1	Liver Diseases (Liver Disease) 11/2019
1	Alcoholic Hepatitis 11/2019
1	Autolysis 01/2018
1	Starvation 08/2013
1	Bovine Mastitis 04/2012
1	Macular Degeneration (Age-Related Maculopathy) 07/2011
1	Prostatic Neoplasms (Prostate Cancer) 09/2009
1	Malaria 01/2009
1	Alzheimer Disease (Alzheimer's Disease) 11/2008
1	Atherosclerosis 11/2008
1	Inflammation (Inflammations) 07/2008
1	Bacterial Infections (Bacterial Infection) 11/2003

Drug/Important Bio-Agent (IBA)

16	Peptides (Polypeptides)IBA 01/2021 - 07/2002
13	Amino Acids FDA Link 01/2021 - 01/2004
12	Sulfides (Thioethers)IBA 01/2020 - 07/2002
10	Bacteriocins (Lantibiotics)IBA 03/2016 - 07/2002
9	Ligases (Synthetase)IBA 01/2020 - 02/2006
8	EnzymesIBA 04/2013 - 11/2005
7	lanthionineIBA 01/2021 - 11/2006
6	Anti-Bacterial Agents (Antibiotics)IBA 01/2021 - 01/2009
6	AcidsIBA 01/2021 - 03/2009
6	dehydrobutyrineIBA 01/2019 - 02/2006
6	dehydroalanineIBA 01/2019 - 05/2007
6	lacticin 481IBA 01/2016 - 02/2006
6	Sulfhydryl Compounds (Thiols)IBA 05/2015 - 10/2005
5	Protein Sorting Signals (Signal Peptide)IBA 01/2018 - 07/2008
5	Serine (L-Serine)FDA Link 04/2013 - 10/2004
4	Fosfomycin FDA Link 01/2021 - 01/2009
4	Proteins (Proteins, Gene)FDA Link 12/2015 - 07/2002
4	Threonine (L-Threonine)FDA Link 04/2013 - 10/2004
3	Biological ProductsIBA 01/2021 - 03/2010
3	NisinIBA 01/2019 - 11/2003
3	Hydro-Lyases (Dehydratases)IBA 01/2019 - 05/2007
3	Glu Transfer RNAIBA 01/2018 - 12/2015
3	Phosphates (Orthophosphate)IBA 07/2015 - 05/2007
3	Cysteine (L-Cysteine)FDA Link 09/2009 - 07/2002
2	Organophosphonates (Phosphonates)IBA 01/2021 - 01/2017
2	PerforinIBA 11/2019 - 03/2019
2	Glutamic Acid (Glutamate)FDA Link 01/2019 - 01/2015
2	DisulfidesIBA 01/2018 - 07/2011
2	LipoxygenasesIBA 11/2008 - 07/2008
1	Pharmaceutical PreparationsIBA 01/2021
1	Epoxy Compounds (Epoxides)IBA 01/2021
1	Therapeutic UsesIBA 11/2019
1	Ethanol (Ethyl Alcohol)IBA 11/2019
1	Protease Inhibitors (Protease Inhibitor)IBA 03/2019
1	Transfer RNA (tRNA)IBA 01/2019
1	Peptide Hydrolases (Proteases)FDA Link 01/2018
1	duramycinIBA 01/2017
1	Antiviral Agents (Antivirals)IBA 01/2017
1	Phosphotransferases (Kinase)IBA 07/2015
1	DeuteriumIBA 07/2014
1	Phosphorus (Red Phosphorus)IBA 08/2013
1	goadsporinIBA 04/2013
1	Multifunctional EnzymesIBA 09/2012
1	nisin AIBA 04/2012
1	Lactic Acid (Lactate)FDA LinkGeneric 07/2011
1	compstatinIBA 07/2011
1	Complement Inactivating AgentsIBA 07/2011
1	Lipoxygenase (Lipoxygenase-1)IBA 09/2009
1	HerbicidesIBA 01/2009
1	3- (N- acetyl- N- hydroxy)aminopropylphosphonic acidIBA 01/2009
1	phosphinothricin (Basta)IBA 01/2009
1	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 11/2008
1	Alanine (L-Alanine)FDA Link 05/2007
1	Mutant Proteins (Protein, Mutant)IBA 05/2007
1	LigandsIBA 05/2007
1	ZincIBA 05/2007
1	Adenosine Triphosphate (ATP)IBA 11/2005